Experimental validation of survival calculations in the presence of motion

The software TRiP98 [1] is successfully used at GSI for treatment planning of stationary tumors. It is capable to calculate the absorbed dose and the biologically effective dose resulting from the superposition of usually several thousand C-12 pencil beams. Treatment is delivered with the raster scanner system [2]. If the target is subject to respiratory motion, treatment is not yet possible because target motion and scanning motion interfere and dose homogeneity is lost. As part of the GSI motion compensation project (see [3]) TRiP98 was extended to calculate the distribution of the absorbed dose in the presence of motion [4]. Recently, we included calculation of cell survival.